Cardiac Arrest Induces Ischemic Long-Term Potentiation of Hippocampal CA1 Neurons That Occludes Physiological Long-Term Potentiation
نویسندگان
چکیده
منابع مشابه
P19: Long-Term Potentiation
The term synaptic plasticity points to a series of persistent changes related to the activity of synapses. Long-term potentiation (LTP) is a reflection of synaptic plasticity that has an important role in learning and memory. LTP is a long-lasting increase of synaptic activity due to enhancement of excitatory synaptic transmission after a high-frequency train of electrical stimulations. Differe...
متن کاملBlock of 5-HT2 Receptors Enhances Hippocampal Long-Term Potentiation
The effect of endogenous serotonin on long-term potentiation (LTP) in region CAI was studied by blocking 5-HT2 receptors with ketanserin in rat hippocampal slices. Such a block significantly en-hanced long-term potentiation of the CAI population spike induced by high frequency stimulation of the schaffer collateral/ commissural pathway. This implies that serotonin acts on 5-HT2 receptors in CAI...
متن کاملP18: Signaling Pathway in Long-Term Potentiation
Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...
متن کاملPostsynaptic density-95 mimics and occludes hippocampal long-term potentiation and enhances long-term depression.
Previous studies have shown that overexpression of the protein PSD-95 (postsynaptic density-95) selectively enhances AMPA receptor-mediated synaptic responses in hippocampal pyramidal cells. To determine whether this effect is related to synaptic plasticity at these synapses, we examined whether PSD-95 expression mimics long-term potentiation (LTP), and also whether it influences LTP and long-t...
متن کاملNeuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses.
Neuregulin-1 (NRG-1) has been identified genetically as a schizophrenia susceptibility gene, but its function in the adult brain is unknown. Here, we show that NRG-1beta does not affect basal synaptic transmission but reverses long-term potentiation (LTP) at hippocampal Schaffer collateral-->CA1 synapses in an activity- and time-dependent manner. Depotentiation by NRG-1beta is blocked by two st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neural Plasticity
سال: 2018
ISSN: 2090-5904,1687-5443
DOI: 10.1155/2018/9275239